Movement Disorder Evaluation

Important

This report is intended to assist qualified Health Care Profesionals (HCP) in the assessment of an individual referred under the suspicion of having Parkinson’s Disease.

Clinical Context

This report presents several AI metrics derived from objective measures from individuals performing a battery of test using Manus Neurodynamica NeuroMotor PenTM.

These presented metrics combine factors from detailed measurement recordings made whilst the individual performs a battery of well established neurological test tasks.

The metrics have been assessed in a UK reference population and an individual’s results are presented in this clinical context. The HCP should review Clinical,Reference, Study et al [1] to establish applicability and limitations.

The information in this report should be used in the context of a full neurological assessment conducted to the current standard of care practices to establish a diagnosis.

Subject and Recording Details

Subject ID NMC 046
Test administered by neuromedic@manusdevices.net
Test date and time 2022-08-31 11:46
Test battery Circle, Spiral, Elel, FITTS Short Modified, FITTS Long Modified, ZigZag, ZigZag Offset
Operator comment

Overall Assessment

PD

Subject performance similar to PD population (recommend review of report details)

Clinical context

In the clinical reference population, 2 individuals with a value less than 0.51 were subsequently diagnosed with PD. That is, 4.76% of the PD diagnoses in the study.

Additionally, 0 individuals with a value greater or equal to 0.51 were subsequently diagnosed as non PD. That is, 0.0% of the non PD diagnoses in the study.

Symptom Scores

These mini boxplots show the scores in a clinical context. Currently against the ‘Walker study’ data. A bigger pool would be much better (so max 83 individuals, usually lower if raw data did not result in successful classification).

The scores are ‘relative to the PD cohort’ and this is how they should be interpreted. A consequence of this is that a low tremor score below may actually correspond to obvious tremor in the raw data, and vice versa.

Micrographia

The micrographia symptom assessment is derived from a combination of factors in the elel task.

{'FN': 1, 'TN': 2, 'TP': 41, 'FP': 28}

Tremor

The tremor score is a combination of features in the circle, spiral and both zizag tasks.

{'FN': 20, 'TN': 17, 'TP': 22, 'FP': 13}

Bradykinesia

The bradykinesia score is a combination of features in the circle, spiral, both zizag and elel tasks.

{'FN': 7, 'TN': 6, 'TP': 35, 'FP': 24}

Spatial Accuracy

The accuracy score is a combination of factors in the spiral, both zigzags and both Fitts tasks.

{'FN': 13, 'TN': 9, 'TP': 29, 'FP': 21}

Test Battery Details

Circle

numCircles 10
timePerCircleMean 6.628
timePerCircleCoV 0.282696
timePerCircleSlope -0.00391361
meanError 1.76635
tremorFreq 7.42188
tremorRelPower 26.882
tremorGyroAmpMean 0.0181026
tremorGyroAmpSlope -0.000962702
tremorGyroAmpCoV 0.515684
tremorCoordAmpMean 0.0362961
tremorCoordAmpSlope 0.00460628
tremorCoordAmpCoV 0.536484
tremorAccAmpMean 0.0180804
tremorAccAmpSlope -0.00136329
tremorAccAmpCoV 0.410274
tremorPcRelVar 0.674096
tremorPcX 0.0828138
tremorPcY -0.996565

Circle Segment 1

Duration 6.6 s, Accuracy Estimate 1.265 (lower is better)

Circle Segment 2

Duration 5.84 s, Accuracy Estimate 1.689 (lower is better)

Circle Segment 3

Duration 6.64 s, Accuracy Estimate 2.099 (lower is better)

Circle Segment 4

Duration 5.44 s, Accuracy Estimate 1.648 (lower is better)

Circle Segment 5

Duration 6.76 s, Accuracy Estimate 1.969 (lower is better)

Circle Segment 6

Duration 11.76 s, Accuracy Estimate 1.902 (lower is better)

Circle Segment 7

Duration 5.56 s, Accuracy Estimate 1.522 (lower is better)

Circle Segment 8

Duration 5.6 s, Accuracy Estimate 1.723 (lower is better)

Circle Segment 9

Duration 6.44 s, Accuracy Estimate 1.435 (lower is better)

Circle Segment 10

Duration 5.64 s, Accuracy Estimate 2.413 (lower is better)

Spiral

numSpirals 10
timePerSpiralMean 16.956
timePerSpiralCoV 0.083549
timePerSpiralSlope -0.00201591
meanError 1.78027
tremorFreq 7.42188
tremorRelPower 32.4221
tremorGyroAmpMean 0.0220268
tremorGyroAmpSlope 0.00212966
tremorGyroAmpCoV 0.496015
tremorCoordAmpMean 0.0553204
tremorCoordAmpSlope -0.00612322
tremorCoordAmpCoV 2.16591
tremorAccAmpMean 0.0219991
tremorAccAmpSlope 0.0015634
tremorAccAmpCoV 0.381559
tremorPcRelVar 0.536609
tremorPcX 0.1852
tremorPcY -0.982701

Spiral Segment 1

Duration 18.88 s, Accuracy Estimate 1.52 (lower is better)

Spiral Segment 2

Duration 14.56 s, Accuracy Estimate 3.061 (lower is better)

Spiral Segment 3

Duration 16.48 s, Accuracy Estimate 1.702 (lower is better)

Spiral Segment 4

Duration 17.24 s, Accuracy Estimate 1.552 (lower is better)

Spiral Segment 5

Duration 17.64 s, Accuracy Estimate 1.57 (lower is better)

Spiral Segment 6

Duration 18.36 s, Accuracy Estimate 1.79 (lower is better)

Spiral Segment 7

Duration 15.16 s, Accuracy Estimate 1.729 (lower is better)

Spiral Segment 8

Duration 18.2 s, Accuracy Estimate 1.741 (lower is better)

Spiral Segment 9

Duration 17.12 s, Accuracy Estimate 1.493 (lower is better)

Spiral Segment 10

Duration 15.92 s, Accuracy Estimate 1.643 (lower is better)

Elel

eDurationMean 0.460395
eDurationStd 0.0793247
eDurationStdnorm 0.172297
eDurationMedian 0.4575
eDurationQuartdelta 0.105
eDurationQuartdeltanorm 0.229508
eDurationKurt 3.38688
eDurationTrenddiff -0.015
eDurationTrendratio 0.967742
eWidthMean 11.232
eWidthStd 3.91538
eWidthStdnorm 0.348592
eWidthMedian 10.2375
eWidthQuartdelta 4.797
eWidthQuartdeltanorm 0.468571
eWidthKurt 2.85352
eWidthTrenddiff 2.34
eWidthTrendratio 1.25641
eHeightMean 12.6114
eHeightStd 3.07853
eHeightStdnorm 0.244107
eHeightMedian 11.934
eHeightQuartdelta 3.159
eHeightQuartdeltanorm 0.264706
eHeightKurt 5.49815
eHeightTrenddiff 1.404
eHeightTrendratio 1.12766
eAspectMean 0.889896
eAspectStd 0.217674
eAspectStdnorm 0.244606
eAspectMedian 0.861002
eAspectQuartdelta 0.285209
eAspectQuartdeltanorm 0.331252
eAspectKurt 2.48296
eAspectTrenddiff 0.0813367
eAspectTrendratio 1.10126
eSlantMean 0.133065
eSlantStd 0.178732
eSlantStdnorm 1.34319
eSlantMedian 0.124332
eSlantQuartdelta 0.196448
eSlantQuartdeltanorm 1.58004
eSlantKurt 2.88834
eSlantTrenddiff 0.00623886
eRtopMean 0.722703
eRtopStd 0.0998363
eRtopStdnorm 0.138143
eRtopMedian 0.74564
eRtopQuartdelta 0.155225
eRtopQuartdeltanorm 0.208177
eRtopKurt 2.47899
eRtopTrenddiff -0.0144388
eRbotMean 0.582679
eRbotStd 0.141945
eRbotStdnorm 0.243607
eRbotMedian 0.567264
eRbotQuartdelta 0.2048
eRbotQuartdeltanorm 0.361031
eRbotKurt 2.99767
eRbotTrenddiff 0.0273696
eRrightMean 0.805338
eRrightStd 0.119281
eRrightStdnorm 0.148113
eRrightMedian 0.828444
eRrightQuartdelta 0.0700565
eRrightQuartdeltanorm 0.084564
eRrightKurt 12.8939
eRrightTrenddiff -0.0222437
eRleftMean 0.340558
eRleftStd 0.0812962
eRleftStdnorm 0.238714
eRleftMedian 0.340972
eRleftQuartdelta 0.125138
eRleftQuartdeltanorm 0.367005
eRleftKurt 1.99973
eRleftTrenddiff 0.0115566
lDurationMean 0.615882
lDurationStd 0.105669
lDurationStdnorm 0.171573
lDurationMedian 0.5975
lDurationQuartdelta 0.115
lDurationQuartdeltanorm 0.192469
lDurationKurt 6.41678
lDurationTrenddiff -0.115
lDurationTrendratio 0.825758
lWidthMean 18.3828
lWidthStd 3.47099
lWidthStdnorm 0.188818
lWidthMedian 17.3745
lWidthQuartdelta 4.563
lWidthQuartdeltanorm 0.262626
lWidthKurt 2.73551
lWidthTrenddiff 4.095
lWidthTrendratio 1.24823
lHeightMean 31.9341
lHeightStd 4.42054
lHeightStdnorm 0.138427
lHeightMedian 32.3505
lHeightQuartdelta 6.552
lHeightQuartdeltanorm 0.202532
lHeightKurt 2.24002
lHeightTrenddiff -2.925
lHeightTrendratio 0.912281
lAspectMean 0.582798
lAspectStd 0.118974
lAspectStdnorm 0.204142
lAspectMedian 0.532378
lAspectQuartdelta 0.199519
lAspectQuartdeltanorm 0.37477
lAspectKurt 1.92723
lAspectTrenddiff 0.155
lAspectTrendratio 1.3065
lSlantMean 0.272555
lSlantStd 0.106896
lSlantStdnorm 0.392199
lSlantMedian 0.257219
lSlantQuartdelta 0.122386
lSlantQuartdeltanorm 0.475806
lSlantKurt 2.78352
lSlantTrenddiff 0.0380381
lRtopMean 0.878704
lRtopStd 0.0519731
lRtopStdnorm 0.0591474
lRtopMedian 0.878609
lRtopQuartdelta 0.0811869
lRtopQuartdeltanorm 0.0924039
lRtopKurt 2.63263
lRtopTrenddiff 0.0210747
lRbotMean 0.412671
lRbotStd 0.131116
lRbotStdnorm 0.317724
lRbotMedian 0.424209
lRbotQuartdelta 0.169909
lRbotQuartdeltanorm 0.400531
lRbotKurt 2.46978
lRbotTrenddiff 0.100623
lRrightMean 0.911215
lRrightStd 0.0402273
lRrightStdnorm 0.0441468
lRrightMedian 0.917959
lRrightQuartdelta 0.032474
lRrightQuartdeltanorm 0.0353763
lRrightKurt 7.38718
lRrightTrenddiff 0.00148064
lRleftMean 0.160559
lRleftStd 0.0567199
lRleftStdnorm 0.353264
lRleftMedian 0.155916
lRleftQuartdelta 0.0638937
lRleftQuartdeltanorm 0.409796
lRleftKurt 3.84525
lRleftTrenddiff 0.0158893

Elel Segment 1

Elel Segment 2

Elel Segment 3

Elel Segment 4

Elel Segment 5

Elel Segment 6

Elel Segment 7

Elel Segment 8

Elel Segment 9

Elel Segment 10

FITTS Short Modified

meanTouchScore 0.874584
sumTouchScores 13.9933
meanMovementTime 0.973
numTouches 16
undershootPercentage 0
overshootPercentage 12.5

FITTS Long Modified

meanTouchScore 0.738724
sumTouchScores 14.0357
meanMovementTime 0.973056
numTouches 19
undershootPercentage 5.26316
overshootPercentage 36.8421

ZigZag

numZigzags 5
timePerZigzagMean 15.416
timePerZigzagCoV 0.101685
timePerZigzagSlope -0.0586404
meanError 2.44285
tremorFreq 6.34766
tremorRelPower 32.869
tremorGyroAmpMean 0.0374649
tremorGyroAmpSlope 0.00316851
tremorGyroAmpCoV 0.332937
tremorCoordAmpMean 0.067593
tremorCoordAmpSlope -0.000378285
tremorCoordAmpCoV 0.278498
tremorAccAmpMean 0.0619734
tremorAccAmpSlope -0.00135407
tremorAccAmpCoV 0.199947
tremorPcRelVar 0.581263
tremorPcX 0.362948
tremorPcY 0.931809

ZigZag Segment 1

Duration 16.72 s, Accuracy Estimate 2.166 (lower is better)

ZigZag Segment 2

Duration 17.04 s, Accuracy Estimate 2.471 (lower is better)

ZigZag Segment 3

Duration 15.0 s, Accuracy Estimate 2.355 (lower is better)

ZigZag Segment 4

Duration 15.2 s, Accuracy Estimate 2.635 (lower is better)

ZigZag Segment 5

Duration 13.12 s, Accuracy Estimate 2.586 (lower is better)

ZigZag Offset

numZigzags 5
timePerZigzagMean 12.216
timePerZigzagCoV 0.196567
timePerZigzagSlope -0.119515
zigzagHeightMean 67.4582
zigzagHeightCoV 0.0846423
zigzagHeightSlope -0.0443764
meanError 0.0487634
tremorFreq 6.25
tremorRelPower 33.3249
tremorGyroAmpMean 0.0430391
tremorGyroAmpSlope 0.00477407
tremorGyroAmpCoV 0.399136
tremorCoordAmpMean 0.0777529
tremorCoordAmpSlope 0.00966798
tremorCoordAmpCoV 0.548066
tremorAccAmpMean 0.0835722
tremorAccAmpSlope 0.000576959
tremorAccAmpCoV 0.0989251
tremorPcRelVar 0.739435
tremorPcX 0.241376
tremorPcY 0.970432

ZigZag Offset Segment 1

Duration 15.92 s, Accuracy Estimate 0.058 (lower is better)

ZigZag Offset Segment 2

Duration 12.76 s, Accuracy Estimate 0.029 (lower is better)

ZigZag Offset Segment 3

Duration 11.84 s, Accuracy Estimate 0.038 (lower is better)

ZigZag Offset Segment 4

Duration 11.12 s, Accuracy Estimate 0.038 (lower is better)

ZigZag Offset Segment 5

Duration 9.44 s, Accuracy Estimate 0.081 (lower is better)

Appendices

Misc

Currently a dumping ground for things that could be included or previous output style.

Note

Putting all the results out here but will not be in a final report.

HiSpec {‘HiSpec_class’: ‘PD’, ‘HiSpec_score’: 0.31}
RanFor {‘RanFor_class’: ‘PD’, ‘RanFor_score’: 0.51}
BM_May22 {‘BM_May22_class’: ‘NOT PD’, ‘BM_May22_score’: 0.46709283998517437}
BM_HC_Sep22 {‘BM_HC_Sep22_class’: ‘Patient’, ‘BM_HC_Sep22_score’: 0.8626863670104445}
BM_PD_Sep22 {‘BM_PD_Sep22_class’: ‘nonPD’, ‘BM_PD_Sep22_score’: 0.3652865082052834}